Increased aortic pulse wave velocity in middle aged women with systemic lupus erythematosus
Identifieur interne : 001D15 ( Main/Exploration ); précédent : 001D14; suivant : 001D16Increased aortic pulse wave velocity in middle aged women with systemic lupus erythematosus
Auteurs : N. Bjarneg Rd [Suède] ; C. Bengtsson [Suède] ; J. Brodszki [Suède] ; G. Sturfelt ; O. Nived [Suède] ; T. L Nne [Suède]Source :
- Lupus [ 0961-2033 ] ; 2006-10.
English descriptors
- Teeft :
- Antimalarial drugs, Aortic, Aortic augmentation index, Aortic stiffness, Applanation tonometry, Arterial pressure, Arterial stiffness, Arthritis rheum, Augmentation, Augmentation index, Better treatment, Blood pressure, Body mass index, Brachial, Brachial artery, Cardiovascular, Cardiovascular disease, Cardiovascular mortality, Cardiovascular risk, Carotid, Carotid artery, Carotid plaque, Central aorta, Central pressure, Cohort, Complement factor, Connective tissue disease, Control subjects, Coronary heart disease, Disease activity, Disease activity index, Early mortality, Erythematosus, Essential hypertension, Higher aortic, Hypertension, Independent risk factor, Late systolic pressure augmentation, Less distensible, Lund, Lund university hospital, Lupus, Lupus erythematosus, Lupus pulse waves, Mmhg, Mortality peak, Muscle cells, Muscular arteries, Myocardial infarction, Natural logarithm, Positive association, Possible difference, Present study, Pressure wave, Pulse pressure, Pulse wave analysis, Pulse wave recordings, Pulse wave velocity, Pulse waves, Radial artery pressure waveform, Rheumatology damage index, Right carotid artery, Risk factors, Serum levels, Sphygmocor system, Stiffness, Systemic, Systemic lupus, Systemic lupus erythematosus, Transfer function, University hospital, Waveform.
Abstract
Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiffness and central hemodynamics in women with SLE in comparison to controls. Arterial tonometry was used to measure aortic (carotid-femoral) and arm (carotid-radial) pulse wave velocity (PWV), reflected pressure waves, and aortic augmentation index (AIx) in 27 women with SLE (52 to 68 years) and 27 controls. Aortic PWV was higher in women with SLE than controls, 9.8 m/s versus 8.2 m/s (P 0.01), after correction for mean arterial pressure and body mass index, 9.5 m/s versus 8.5 m/s (P 0.05). Other parameters were similar, arm PWV, 8.4 versus 8.5 m/s, AIx 34 versus 33% and calculated central aortic pulse pressure 48 versus 43 mmHg, in SLE and controls, respectively (NS). Aortic PWV was positively associated to C-reactive protein (CRP) and complement factor 3 (C3). Women with SLE have increased stiffness of their elastic central arteries. This may be one factor contributing to the increased cardiovascular risk seen in this cohort.
Url:
DOI: 10.1177/0961203306071402
Affiliations:
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L Nne</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine and Care, University of Linköping</wicri:regionArea><wicri:noRegion>University of Linköping</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Lupus</title><idno type="ISSN">0961-2033</idno><idno type="eISSN">1477-0962</idno><imprint><publisher>Sage Publications</publisher><pubPlace>Sage CA: Thousand Oaks, CA</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="644">644</biblScope><biblScope unit="page" to="650">650</biblScope></imprint><idno type="ISSN">0961-2033</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0961-2033</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antimalarial drugs</term><term>Aortic</term><term>Aortic augmentation index</term><term>Aortic stiffness</term><term>Applanation tonometry</term><term>Arterial pressure</term><term>Arterial stiffness</term><term>Arthritis rheum</term><term>Augmentation</term><term>Augmentation index</term><term>Better treatment</term><term>Blood pressure</term><term>Body mass index</term><term>Brachial</term><term>Brachial artery</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular mortality</term><term>Cardiovascular risk</term><term>Carotid</term><term>Carotid artery</term><term>Carotid plaque</term><term>Central aorta</term><term>Central pressure</term><term>Cohort</term><term>Complement factor</term><term>Connective tissue disease</term><term>Control subjects</term><term>Coronary heart disease</term><term>Disease activity</term><term>Disease activity index</term><term>Early mortality</term><term>Erythematosus</term><term>Essential hypertension</term><term>Higher aortic</term><term>Hypertension</term><term>Independent risk factor</term><term>Late systolic pressure augmentation</term><term>Less distensible</term><term>Lund</term><term>Lund university hospital</term><term>Lupus</term><term>Lupus erythematosus</term><term>Lupus pulse waves</term><term>Mmhg</term><term>Mortality peak</term><term>Muscle cells</term><term>Muscular arteries</term><term>Myocardial infarction</term><term>Natural logarithm</term><term>Positive association</term><term>Possible difference</term><term>Present study</term><term>Pressure wave</term><term>Pulse pressure</term><term>Pulse wave analysis</term><term>Pulse wave recordings</term><term>Pulse wave velocity</term><term>Pulse waves</term><term>Radial artery pressure waveform</term><term>Rheumatology damage index</term><term>Right carotid artery</term><term>Risk factors</term><term>Serum levels</term><term>Sphygmocor system</term><term>Stiffness</term><term>Systemic</term><term>Systemic lupus</term><term>Systemic lupus erythematosus</term><term>Transfer function</term><term>University hospital</term><term>Waveform</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiffness and central hemodynamics in women with SLE in comparison to controls. Arterial tonometry was used to measure aortic (carotid-femoral) and arm (carotid-radial) pulse wave velocity (PWV), reflected pressure waves, and aortic augmentation index (AIx) in 27 women with SLE (52 to 68 years) and 27 controls. Aortic PWV was higher in women with SLE than controls, 9.8 m/s versus 8.2 m/s (P 0.01), after correction for mean arterial pressure and body mass index, 9.5 m/s versus 8.5 m/s (P 0.05). Other parameters were similar, arm PWV, 8.4 versus 8.5 m/s, AIx 34 versus 33% and calculated central aortic pulse pressure 48 versus 43 mmHg, in SLE and controls, respectively (NS). Aortic PWV was positively associated to C-reactive protein (CRP) and complement factor 3 (C3). Women with SLE have increased stiffness of their elastic central arteries. This may be one factor contributing to the increased cardiovascular risk seen in this cohort.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><noCountry><name sortKey="Sturfelt, G" sort="Sturfelt, G" uniqKey="Sturfelt G" first="G" last="Sturfelt">G. Sturfelt</name></noCountry><country name="Suède"><noRegion><name sortKey="Bjarneg Rd, N" sort="Bjarneg Rd, N" uniqKey="Bjarneg Rd N" first="N" last="Bjarneg Rd">N. Bjarneg Rd</name></noRegion><name sortKey="Bengtsson, C" sort="Bengtsson, C" uniqKey="Bengtsson C" first="C" last="Bengtsson">C. Bengtsson</name><name sortKey="Bjarneg Rd, N" sort="Bjarneg Rd, N" uniqKey="Bjarneg Rd N" first="N" last="Bjarneg Rd">N. Bjarneg Rd</name><name sortKey="Brodszki, J" sort="Brodszki, J" uniqKey="Brodszki J" first="J" last="Brodszki">J. Brodszki</name><name sortKey="L Nne, T" sort="L Nne, T" uniqKey="L Nne T" first="T" last="L Nne">T. L Nne</name><name sortKey="Nived, O" sort="Nived, O" uniqKey="Nived O" first="O" last="Nived">O. Nived</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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